Mr. Alexander Keiller

Neonatal Alexander disease: MR imaging prenatal diagnosis.

SUMMARY Alexander disease (AD) is a rare neurodegenerative disorder characterized by megalencephaly, leukoencephalopathy, and Rosenthal fibers within astrocytes. This report describes the case of a female patient with sonography-detected ventriculomegaly at 32 weeks' gestation and distinctive MR imaging features at 33 and 36 weeks' gestation, at birth, and at 2 months of age, which led to the s...

Alexander disease: diagnosis with MR imaging.

BACKGROUND AND PURPOSE To date, the demonstration of Rosenthal fibers on brain biopsy or autopsy specimens is considered a prerequisite for a definitive diagnosis of Alexander disease. We initiated a multiinstitutional survey of MR abnormalities in both presumed and confirmed cases of Alexander disease to assess the possibility of an MR-based diagnosis. METHODS MR imaging studies in three pat...

Can MR imaging diagnose adult-onset Alexander disease?

BACKGROUND AND PURPOSE In recent years, the discovery that mutations in the glial fibrillary acidic protein gene (GFAP) were responsible for Alexander disease (AD) brought recognition of adult cases. The purpose of this study was to demonstrate that MR imaging allows identification of cases of AD with adult onset (AOAD), which are remarkably different from infantile cases. MATERIALS AND METHO...

Infantile Alexander disease: MR appearance of a biopsy-proved case.

Fig. 1.-A, Noncontrast CT scan shows vague area of increased attenuation adjacent to head of right caudate nucleus (arrow). B, Coronal T1-weighted (700/ 20/ 4) MR image shows area of decreased signal in white matter adjacent to, and extending into, head of right caudate nucleus (arrow). C, Axial T1-weighted (600/ 20) postcontrast MR image shows no significant contrast enhancement (arrow). D, Ax...

Alexander Ogilvy